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. Author manuscript; available in PMC: 2021 Dec 13.
Published in final edited form as: J Neurosci Res. 2020 Jun 13;100(1):265–277. doi: 10.1002/jnr.24645

FIGURE 3.

FIGURE 3

No potentiation of Sham active (dark) phase voluntary wheel running by 5 days of systemic morphine co-administered with systemic P2X7 or TLR4 inhibitors. To test whether potentiation of wheel running behavior arose simply as a result of co-administration of morphine with P2X7 or TLR4 antagonists, the paradigm was replicated in sham rats, instead of CCI. Systemic co-administration of morphine with either (+)-NLX nor A438079 (vertical gray bar) failed to alter either running distance (a) or maximum speed (b). n = 5–6 per group