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. 2021 Aug 19;27:92. doi: 10.1186/s10020-021-00351-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — CB2 activation attenuates the degeneration of NPCs. A, B CCK-8 results showing that both JWH133 and AM630 have no toxicity in NPCs at concentrations under 10 µM C RT-qPCR results for collagen II, aggrecan, MMP3 and MMP13 (*p < 0.05). D Representative image of ICC staining for collagen II, aggrecan, MMP3 and MMP13 in NPCs; scale bar, 100 μm. E Western blot results for collagen II, aggrecan, MMP3 and MMP13. (n = 3 Independent experiments)