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. 2021 Aug 19;27:92. doi: 10.1186/s10020-021-00351-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — CB2 Activation alleviates IVDD in vivo. SD rat coccygeal Co 7–8 vertebrae were punctured and treated with JWH133 and AM630. A Representative X-ray images of rats in the 4 groups (Control, Vehicle, JWH133, and AM630). B Quantitative analysis of DHI at different time points after the operation (*p < 0.05 compared with Vehicle group). C Representative MRI image of rats in the 4 groups. D Quantitative analysis of IVD optical density (*p < 0.05). E H&E and safranin O staining of the 4 experimental groups, scale bar, 1000 μm. F Representative IHC images of collagen II and MMP3 in the 4 experimental groups, scale bar, 1000 μm. G Quantitative statistics of the histological scores. H, I Quantitative analysis of the positive staining area for collagen II and MMP3 (p < 0.05). (n = 10 Independent experiments)