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. Author manuscript; available in PMC: 2021 Aug 20.
Published in final edited form as: Sci Transl Med. 2018 May 23;10(442):eaal2563. doi: 10.1126/scitranslmed.aal2563

Fig. 4. Rat NPCs are inhibited by CSPGs.

Fig. 4.

(A and B) Neurite outgrowth from E14 rat spinal cord–derived NPCs was inhibited by CSPG in a dose-dependent manner (***P < 0.001, one-way ANOVA, with *P < 0.05, ***P < 0.001 post hoc Tukey’s test; n = 3 rat spinal cords, n = 2 wells per spinal cord). (C and D) Myelin-dependent neurite outgrowth from rat NPCs derived from rat embryos at different developmental stages was developmentally regulated and declined steadily from E14 to E19 (****P < 0.0001, one-way ANOVA with post hoc Tukey’s test; n = 3 embryos per time point, n = 4 wells per embryo). Values are normalized to the PDL substrate for each individual experiment. Mean ± SEM. Scale bars, 20 μm (A), 30 μm (C).