TABLE 1.
Clinical interventions for corrected QTs interval prolongation.
| Patient | Incident | Intervention |
|---|---|---|
| Patient 7 | 1st incident | No intervention |
| Patient 9 | 1st incident | Clofazimine stopped |
| Magnesium sulphate prescribed | ||
| Patient 11 | 1st incident | One dose of bedaquiline skipped |
| 2nd incident | No intervention | |
| 3rd incident | No intervention | |
| 4th incident | Clofazimine stopped | |
| Patient 12 | 1st incident | No intervention |
| Patient 15 | 1st incident | No intervention |
| Patient 16 | 1st incident | No intervention |
| Patient 18 | 1st incident | Repeat ECG in 1 week |
| Patient 19 | 1st incident | No intervention |
| Patient 20 | 1st incident | Repeat ECG in 24 h |
| 2nd incident | Blood tests, repeat ECG | |
| 3rd incident | Bedaquiline stopped for 1 week | |
| 4th incident | Monitor | |
| 5th incident | Repeat ECG | |
| 6th incident | Repeat ECG | |
| 7th incident | Repeat ECG | |
| 8th incident | Blood tests, weekly ECGs | |
| 9th incident | No intervention | |
| 10th incident | No intervention | |
| Patient 22 | 1st incident | Bedaquiline omitted for 1 week |
| Magnesium sulphate and calcium carbonate prescribed | ||
| Patient 24 | 1st incident | No intervention |
| 2nd incident | Clofazimine stopped | |
| Bedaquiline omitted for 1 week | ||
| Magnesium sulphate and calcium carbonate prescribed | ||
| Patient 25 | 1st incident | Magnesium sulphate prescribed |
ECG, electrocardiogram.