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. 2021 Aug 6;11:689626. doi: 10.3389/fonc.2021.689626

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Copyright © 2021 Zhang, Wang, Lu, Su, Wang, Huang, Zhang and Zhu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Two prognostic subtypes of MIBC were classified using multi-omics data-based deep learning framework. (A) Principal component analysis shows two distinguished MIBC subgroups clustered by K-means algorithm. (B) Kaplan-Meier curves show a significant difference of overall survival between MIBC subtypes. (C) Forest plot shows the multi-variates cox regression analysis result using general clinical characters as well as the predicted MIBC subtypes. (D) Distribution of the MIBC subtypes in various clinical phenotypes.