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. 2021 Aug 6;11:689626. doi: 10.3389/fonc.2021.689626

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Copyright © 2021 Zhang, Wang, Lu, Su, Wang, Huang, Zhang and Zhu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Internal and external validation of prognostic subtyping. (A) ROC analysis shows the robustness of subgroup classification in internal testing dataset using multi-omics data. (B) Kaplan-Meier curves show a significant difference of overall survival between subtypes predicted by multi-omics data in internal testing dataset. (C) ROC analysis shows the robustness of subgroup classification in internal testing dataset using each single omics data, respectively. (D–F). Kaplan-Meier curves show a significant difference of overall survival between subtypes in external datasets, including GSE19915 (D) and two subsets of GSE48277 (E, F), respectively.