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. 2021 Aug 6;11:686044. doi: 10.3389/fonc.2021.686044

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Copyright © 2021 Yang, Li, Qin, Zhang, Zhao, Wang, Huang and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of prognostic DEGs related to FRGs in the TCGA cohort. (A) The 67 overlapping genes were shown in the volcano map. Forty genes were upregulated and 27 genes were downregulated in tumor tissues. (B) Venn diagram to identify DEGs related to FRGs. (C) Univariate Cox proportional regression analysis showed that the 12 genes were significantly associated with OS. (D) A heatmap showing the expressions of the 12 prognostic genes in the tumors and normal tissues. (E) PPI network provided interactive information among the candidate prognostic genes. (F) The correlation network of candidate genes. Different colors represented the correlation coefficients.