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. 2021 Aug 6;9:715093. doi: 10.3389/fcell.2021.715093

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Copyright © 2021 Helle, Ampuja, Dainis, Antola, Temmes, Tolvanen, Mervaala and Kivelä.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Single-cell transcriptome of six combined samples [(1) HEL24.3 hiPS-EC monoculture, (2) HEL24.3 hiPS-CM monoculture, (3) HEL24.3 co-culture of hiPS-CMs and hiPS-ECs, (4) HEL47.2 hiPS-EC monoculture, (5) HEL24.3 hiPS-CM monoculture, and (6) HEL47.2 co-culture of hiPS-CMs and hiPS-ECs]. (A) Uniform Manifold Approximation and Projection (UMAP) plot of delineated clusters. Endothelial cells (EC), cardiomyocytes (CM), mesenchymal cells (MC), and poorly differentiated ECs have been highlighted. (B) The same UMAP plot according to cell culture conditions [(1) hiPS-EC monoculture (green), (2) hiPS-CM monoculture (red), and (3) hiPS-EC/hiPS-CM co-culture (blue)]. (C) The same UMAP plot according to cell line (1) HEL24.3 (salmon), and (2) HEL47.2 (skyblue). Feature plots on the expression of (D) vascular endothelial markers (E) cardiomyocyte markers (F) lymphatic endothelial cell markers.