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. 2021 Aug 6;9:715093. doi: 10.3389/fcell.2021.715093

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Copyright © 2021 Helle, Ampuja, Dainis, Antola, Temmes, Tolvanen, Mervaala and Kivelä.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of co-culture and monoculture hiPS-CMs. (A) Volcano plot of altered genes in co-culture hiPS-CMs compared to monoculture hiPS-CMs. (B) GO-analysis on differentially expressed genes that are upregulated (fold change > 0.10) in co-culture hiPS-CMs–eight representative categories are presented. (C) Upregulated genes in three relevant GO categories. (D) The sarcomeric gene TCAP, and FTH1 and FTL that build the cytoplasmic iron storage protein ferritin, were all significantly downregulated in co-culture hiPS-CMs. All scRNAseq data presented in the figure consists of combined data from HEL47.2 and HEL24.3 lines.