. Author manuscript; available in PMC: 2021 Aug 20.

Published in final edited form as: Regul Toxicol Pharmacol. 2020 Jun 30;116:104716. doi: 10.1016/j.yrtph.2020.104716

Table 5:

Summary of Blood Pressure Data- Treatment and Recovery (MALE)

Dose Group		Week 4 (Approximately 2 Hours Post-Dose)
		Blood Pressure		Arterial Pressure	Heartbeats per minute
		Systolic (mmHg)	Diastolic (mmHg)	Arterial Pressure	Heartbeats per minute
G 1 / M 0 mg/kg	Mean	135 ^a	86 ^a	98 ^a	102 ^a
	S.D.	15.5	20.7	16.0	27.2
	N	5	5	5	5

G 2 / M 0.25 mg/kg	Mean	154	103	115	124
	S.D.	27.2	18.3	18.0	37.4
	N	5	5	5	5

G 3 / M 0.75 mg/kg	Mean	156	92	108	95
	S.D.	50.6	36.6	38.4	25.9
	N	5	5	5	5

G 4 / M 1.50 mg/kg	Mean	164	106	122	94
	S.D.	40.0	37.4	34.7	46.6
	N	5	5	5	5
Dose Group		Week 8^b
		Blood Pressure		Arterial Pressure	Heartbeats per minute
		Systolic (mmHg)	Diastolic (mmHg)	Arterial Pressure	Heartbeats per minute

G 1 / M 0 mg/kg	Mean	124	75	90	124
	S.D.	21.2	3.5	8.5	24.0
	N	2	2	2	2

G 2 / M 0.25 mg/kg	Mean	182	113	129	113
	S.D.	16.3	12.0	11.3	21.2
	N	2	2	2	2

G 3 / M 0.75 mg/kg	Mean	174	116	131	136
	S.D.	42.4	42.4	36.1	16.3
	N	2	2	2	2

G 4 / M 1.50 mg/kg	Mean	154	116	126	108
	S.D.	26.9	1.4	8.5	60.1
	N	2	2	2	2

ANOVA

Recovery phase data not statistically analyzed due to the small number of animals.