Table 7:

Dose Proportionality of Mean C_max and AUC_last from 0.25 to 1.5 mg/kg in Female and Male Dogs on Days 1 and 27 after Oral Administration of Metarrestin

Day	Sex	Dose (mg/kg)	Fold-increase	Cmax ng/mL	Fold-increase	AUClast hr*ng/mL	Fold-increase
1	Female	0.25	1.00	33.7	1.00	1259	1.00
		0.75	3.00	81.9	2.43	2822	2.24
		1.5	6.00	228	6.76	7831	6.22
	Male	0.25	1.00	37.2	1.00	1068	1.00
		0.75	3.00	102	2.76	2919	2.73
		1.5	6.00	278	7.49	7176	6.72
28	Female	0.25	1.00	78.2	1.00	2778	1.00
		0.75	3.00	220	2.82	6998	2.52
		1.5	6.00	544	6.96	18407	6.63
	Male	0.25	1.00	87.4	1.00	2264	1.00
		0.75	3.00	289	3.31	9077	4.01
		1.5	6.00	429	4.91	14630	6.46