Table 1. Univariate and multivariate analysis of overall survival in TCGA patients with ccRCC.

Variables	Univariate analyses		Multivariate analyses
	Hazard ratio (95% CI)	p -value	Hazard ratio (95% CI)	p -value
Age (<60 vs. ≥60)	0.557 (0.406–0.746)	<0.001	0.681 (0.487–0.953)	0.025
Sex (female vs. male)	1.056 (0.773–1.442)	0.734
Laterality (left vs. right)	1.409 (1.042–1.904)	0.026	1.345 (0.972–1.860)	0.073
NEDD4L (low vs. high)	2.323 (1.683–3.208)	<0.001	1.905 (1.330–2.730)	<0.001
T (T1 vs. T2/3/4)	0.336 (0.240–0.470)	<0.001	1.328 (0.707–2.495)	0.378
N (N0 vs.N1/X)	1.106 (0.819–1.493)	0.511
M (M0 vs. M1/X)	0.265 (0.195–0.362)	<0.001	0.828 (0.558–1.231)	0.351
Cancer status (tumor free vs. with tumor)	0.195 (0.140–0.273)	<0.001	0.334 (0.225–0.495)	<0.001
Stage (stage I vs. stage II/III/IV)	0.253 (0.183–0.349)	<0.001	0.447 (0.240–0.834)	0.011
Grade (G1/2 vs. G3/4)	0.374 (0.265–0.529)	<0.001	0.759 (0.508–1.134)	0.178