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. 2021 Aug 19;11(8):e050285. doi: 10.1136/bmjopen-2021-050285

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Flow diagram of the study population. Children with relapse/SMN and matched references in first remission. *Matching on age group, sex, risk group and treatment protocol. †The number in brackets is the number of unique persons—the same child can serve as a control more than once and controls can later become cases. BCR-ALL or T-ALL, B-cell precursor or T-lineage acute lymphoblastic leukaemia; CPR number, civil personal registration number; HSCT in CR1, haematopoietic stem cell transplantation in first complete remission; SMN, second malignant neoplasm.