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. 2021 Aug 19;11(8):e050285. doi: 10.1136/bmjopen-2021-050285

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Health care utilisation by months before event for cases (n=49) compared with references* (n=243). Cases are survivors of childhood ALL developing a relapse as the first event (cases developing an SMN are excluded in this analysis). Top panel: contacts mean rates per month presented as crude rates. Bottom panel: incidence rate ratios adjusted for age, sex and time since diagnosis. Vertical lines represent 95% CIs. *References, survivors of childhood ALL still in first remission matched on age, sex, treatment protocol and risk group. ALL, acute lymphoblastic leukaemia; SMN, second malignant neoplasm.