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. 2021 Jul 16;52(9):2764–2772. doi: 10.1161/STROKEAHA.120.032935

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© 2021 The Authors.

Stroke is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 2. — Calibration of treatment benefit in the HERMES (Highly Effective Reperfusion Evaluated in Multiple Endovascular Stroke Trials) validation cohort (n=1242), defined as the difference in the observed proportion of functional independence (modified Rankin Scale score 0–2) in treated patients and control patients. Patients were classified into quintiles according to their predicted treatment benefit. C-for-benefit was 0.53 (95% CI, 0.50–0.56).