Table 2.
Multivariable Cox proportional hazards model for overall survival after resection of colorectal liver metastasis in 790 patients
| No. of patients | No. of events | Multivariable analysis |
||
|---|---|---|---|---|
| Hazard ratio * | P | |||
| Largest diameter of colorectal liver metastasis (continuous variable) | – | – | 1.11 (1.06, 1.16) | <0.001 |
| No. of colorectal liver metastases (continuous variable) | – | – | 1.06 (1.03, 1.09) | <0.001 |
| RAS mutation status | ||||
| Mutant | 354 | 179 | 1.76 (1.42, 2.18) | <0.001 |
| Wild type | 436 | 178 | 1.00 (reference) | |
| Age (per year, continuous variable) | – | – | 1.02 (1.01, 1.03) | 0.002 |
| Primary lymph node metastasis | ||||
| Positive | 568 | 268 | 1.58 (1.23, 2.03) | <0.001 |
| Negative | 222 | 89 | 1.00 (reference) | |
| Prehepatectomy chemotherapy | ||||
| Yes | 697 | 318 | 1.47 (1.04, 2.08) | 0.031 |
| No | 93 | 39 | 1.00 (reference) | |
Values in parentheses are 95 per cent confidence intervals. Of 810 patients, 790 were included in the analysis because data were not available for lymph node metastasis in 20 patients.
*
Based on analysis of data from 787 patients with complete data on tumour category and primary lymph node metastasis, the six variables in the table were selected for the final model.