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. 2021 Aug 20;3(3):zcab034. doi: 10.1093/narcan/zcab034

Figure 1.

Figure 1.

G4 binding pocket, catalytic domain, mapped protein interaction sites, and sites for post-translational modifications of FANCJ. Certain key residues are shown, but not all for simplicity. Lys 141 and Lys142 are implicated in G4 binding. The nuclear localization sequence (NLS) and Fe-S domain are comprised by residues 159–174 and residues 270–263, respectively. The conserved PCNA interaction motif (PIP) corresponds to residues 1001–1017. FANCJ directly binds to the RPA70 subunit of the RPA heterotrimer. The FANCJ Q25A substitution disables the ability of FANCJ to effectively dimerize. The binding site on FANCJ for MSH5 (not shown) has not yet been mapped. See text for additional details and references.