Figure 2.

Factors that may contribute to FANCJ’s unique requirement to resolve G4 DNA structures to enable smooth cellular DNA replication of the leading and lagging strands. (A) FANCJ unique ability to efficiently resolve intramolecular G4 DNA. (B) FANCJ expression abundance in a cell-type or tissue-specific manner. (C) FANCJ’s protein partnerships with factors directly involved in replication (e.g. RPA). (D) FANCJ’s post-translational modifications affect catalytic function or replisome association. Factors are not mutually exclusive and may influence one another.