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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Antiviral Res. 2021 Jun 29;193:105125. doi: 10.1016/j.antiviral.2021.105125

Table 3.

Mouse plasma and liver trough levels 24 h after 3rd 100 mg/kg dose

Compound Plasma (μM)a Liver (μM)a
Male Female Male Female
ARN-75039 21.1 ± 5.5 22.1 ± 14.1 71.8 ± 19.4 79.2 ± 66.0
ARN-75041 10.8b 21.2b 150.0 ± 15.1 >200c
a

Data points represent the mean and standard deviation of 3 mice per sex

b

Plasma samples pooled from 3 mice

c

Measured concentration above the upper limit of the standard curve