Table 4.
Independent Predictors of Negative Clinical Outcomes
| Variable | OR (95% CI) | P Value | aOR (95% CI) | P Value |
|---|---|---|---|---|
| Timely MEVa | 0.387 (0.098–1.522) | .174 | 0.277 (0.081–0.941) | .040 |
| APACHE II score | 1.083 (1.012–1.159) | .021 | 1.095 (1.029–1.166) | .004 |
| Nosocomial infectionb | 2.298 (0.583–9.055) | .234 | 4.041 (1.132–14.426) | .031 |
| Heart failure | 5.313 (1.188–23.763) | .029 | 4.216 (1.129–15.733) | .032 |
| Intra-abdominal infection | 0.162 (0.022–1.206) | .076 | 0.151 (0.027–0.835) | .030 |
Hosmer-Lemeshow goodness-of-fit: 0.302. Variance inflation factor for all factors in the model: 1–5. Variables in the model: age, APACHE, admission from nursing home, CCI, chronic kidney disease, chronic dialysis, dementia, heart failure, timely MEV, tumor without metastasis, source is an intra-abdominal infection, source is a respiratory tract infection, liver disease, nosocomial infection, surgery within the past 30 days of index culture.
Abbreviations: APACHE II, Acute Physiology and Chronic Health Evaluation; CCI, Charlson Comorbidity Index; CART, classification and regression tree analysis; MEV, meropenem vaborbactam.
aTimely MEV is defined as MEV within 48 hours (ie, at CART breakpoint).
bDefined as infection within 48 hours of inpatient admission date/time.