Fig. 2.

Potential targets of miR-223, miR-98, miR-9, and miR-214 in JAK/STAT pathway. The JAK/STAT signaling pathway is a transducer of a wide variety of signals for development and homeostasis in animals from humans to flies. In mammals, this pathway is the main mechanism of signal transduction from growth factors and cytokines. Following the binding of a cytokine to a receptor, the JAK tyrosine kinase activates STAT. Upon the activation of STAT, it is dimerized and transferred to the nucleus, leading to the regulation of the transcription of target genes. The targets of the miR-223, miR-98, miR-9, and miR-214 in these pathway are shown using red arrows (KEGG PATHWAY database). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)