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. 2021 Aug 20;16(8):e0256396. doi: 10.1371/journal.pone.0256396

Fig 6. Cohort 1: Higher post-5th responses to SPZ are linked to post-5th IFN-γ and IL2 responses to CSP, AMA1, TRAP and CelTOS.

Fig 6

Cohort 1: post-5th IFN-γ and IL2 responses to SPZ, CSP, AMA1, TRAP and CelTOS (C1p = Cohort 1 protected; C1np = Cohort 1 not protected) are color-coded. Subjects with negative SPZ responses are shown in red font. Panel A: Protected: IFN-γ: the highest SPZ IFN-γ responder (C1p4) had IFN-γ responses to TRAP and CelTOS; the third highest SPZ IFN-γ responder (C1p5) had IFN-γ responses to AMA1. The remaining protected subjects were negative to each antigen. Panel B: Non-protected: IFN-γ: the three highest SPZ IFN-γ responders (C1np1, C1np2) had IL2 responses only to AMA1. Panel C: Protected: IL2: the highest SPZ IL2 responder (C1p4) had IL2 responses to CSP, TRAP and CelTOS. The remaining protected subjects were negative with each antigen. Panel D: Non-Protected: IL2: the third and fourth highest SPZ IL2 responders (C1np5, C1np2) had IL2 responses to CSP (C1np5) and AMA1 (C1np5, C1np2).