Fig 7. Cohort 2: Higher post-5^th protective responses to sporozoites are linked to post-5^th protective IFN-γ and IL2 responses to CSP, AMA1, TRAP and CelTOS.

Cohort 2: post-5^th IFN-γ and IL2 responses to SPZ, CSP, AMA1, TRAP and CelTOS (C2p = Cohort 2 protected; C2np = Cohort 2 not protected) are color-coded; subjects with negative responses are shown in red. Panel A: Protected: IFN-γ: the highest SPZ IFN-γ responder (C2p6) had IFN-γ responses to AMA1 and CelTOS; the second highest SPZ IFN-γ responder (C2p8) had IFN-γ responses to AMA1; the third and sixth highest SPZ IFN-γ responders (C2p1, C2p7) had IFN-γ responses to CSP. The remaining five protected subjects were negative with each antigen. Panel B: Non-protected: IFN-γ: the non-protected protected subject (C2np1) had low positive responses to sporozoites and IFN-γ responses to AMA1. Panel C: Protected: IL2: the two highest SPZ IL2 responders (C2p8, C2p6) had IL2 responses to AMA1, TRAP and CelTOS and the fourth highest SPZ IL2 responder (C2p5) had IL2 responses to AMA1. The remaining six protected subjects were negative with each antigen. Panel D: Non-protected: IL2: the non-protected subject (C2np1) had IL2 responses to sporozoites and AMA1.