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. 2021 Aug 19;3(8):e0518. doi: 10.1097/CCE.0000000000000518

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Copyright © 2021 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 1. — Flow chart of enrolled patients in the derivation and validation cohorts with displayed distribution of hyper- versus hypoinflammatory subphenotypes by different types of analyses. The four-variable internal parsimonious model used levels of bicarbonate, tumor necrosis factor receptor (TNFR)–1, angiopoietin-2, and procalcitonin, whereas the three-variable external model used levels of interleukin-8, bicarbonate, and TNFR-1. Prediction with parsimonious models was not possible for 28 of 498 subjects (5.6%) due to missingness of one or more biomarker levels.