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. 2021 Aug 6;13:693890. doi: 10.3389/fnagi.2021.693890

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Copyright © 2021 Huang, Zhang, Tang, Yang, Chen, Tao and Liang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Abnormal white matter estimated by fractional anisotropy (FA) in type 2 diabetes mellitus (T2DM). (A) The results from the activation likelihood estimation (ALE) meta-analyses are shown in 3D rendering. The gray region represents the outline of the brain. The green region represents the normal white matter. The blue region represents the abnormalities in the white matter. (B) The results from the ALE meta-analyses are overlaid onto a standard template in the Montreal Neurological Institute (MNI) space. The color bar represents the ALE value. Cluster-level inference threshold of p < 0.05 [family-wise error (FWE) correction] with 5,000 permutations and p < 0.05.