Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 20;7(34):eabg1694. doi: 10.1126/sciadv.abg1694

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.

PMC Copyright notice

Fig. 1 — (A) UMAP representation of merged dataset with cells color-coded by experimental condition (OSS or Ctrl). (B) UMAP representation of single-cell gene expression showing the four identified clusters. (C) Stacked bar plot showing the relative proportion of clusters in each sample, with total cell counts indicated. (D) Heatmap of unsupervised clustering analysis featuring the top 10 discriminative genes per cluster. (E) UMAP feature plots demonstrating differential expression of selected EndMT genes (PECAM1, VWF, CDH5, VIM, ACTA2, and COL1A1) and genes associated with inflammation (ICAM1, IL6, and CXCL8) in each cluster. (F) Split view of UMAP representation of the segregation of clusters under experimental conditions.