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. 2021 Aug 20;7(34):eabg1694. doi: 10.1126/sciadv.abg1694

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Fig. 2 — (A) UMAP representation of two major subpopulations under experimental conditions. (B) Volcano plot showing statistical significance (P value) versus fold change for differentially expressed genes in cluster QET and cluster PIM-EndMT. (C) GSEA hallmark analysis of the top pathways significantly up-regulated in PIM-EndMT versus QET ECs. (D) GSEA enrichment plots showing that EMT and inflammatory markers are enriched in PIM-EndMT cluster. (E) Violin plots showing the distribution of specific mesenchymal and pro-inflammatory markers in QET and PIM-EndMT clusters. Each dot represents a single cell. NES, normalized enrichment score.