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(a–d) Hematoxylin and eosin (H&E) stained section ((a), ×40 magnification) showing skin with underlying dermis containing an infiltrative vasoformative neoplasm. The endothelial cells lining these vascular spaces are cytologically atypical (inset, H&E ×400 magnification). Immunohistochemistry staining (×200 magnification) showed diffuse positivity in the malignant cells for CD31 (b), patchy staining for C-MYC (c), and nuclear immunoreactivity for ERG (d).
