Table 2.
Sensitivity and specificity analysis of the sVNT using an animal serum panel of nine different species, including SARS-CoV and MERS-CoV positive animals and control animals.
| SARS-CoV-2 |
||||
|---|---|---|---|---|
| Seropositive |
Seronegative |
|||
| 20% | 30% | 20% | 30% | |
| Cynomolgus macaques | 11/13 | 9/13 | 10/10 | 10/10 |
| Rhesus macaques | 9/9 | 9/9 | 10/10 | 10/10 |
| Ferrets | 16/16 | 16/16 | 11/11 | 11/11 |
| Rabbits | 7/7 | 7/7 | 14/14 | 14/14 |
| Hamsters | 4/4 | 4/4 | 4/4 | 4/4 |
| Cats | 6/6 | 6/6 | 9/10 | 10/10 |
| Cattle | 1/1 | 1/1 | 10/10 | 10/10 |
| Mink | 10/10 | 10/10 | – | – |
| MERS-CoV-seropositive | ||||
| Dromedary camels | 13/13 | 13/13 | ||
| Cynomolgus macaques | 2/2 | 2/2 | ||
| Sensitivity | Specificity | |||
| 20% | 30% | 20% | 30% | |
| All data | 97.0 | 93.9 | 99.07 | 100 |
| PRNT50 20–80 | 92.9 | 85.7 | ||
| PRNT50 > 80 | 100 | 100 | ||