FIGURE 1.

Characterizing sorafenib primary resistance cell in HCC by Single-Cell RNA-Seq. (A) Workflow of the sample preparation, sequencing and bioinformatic analysis (B) Statistics of survival rate of three groups of PDX model mice. Tumor tissues of three HCC patients were grown as orthotopic xenografts. In the control group, NCG mice were treated with saline intravenously (i.v.); in the model group, PDX model mice were treated with saline intravenously (i.v.). Above two groups were injected once daily (qd) for 35 days. In the sorafenib group, PDX model mice were treated with 50 mg/kg via oral gavage, once daily for 35 days. All PDX mice were sacrificed on the 35th day.