Table 4.
Pooled proportions (with their 95% confidence interval) for the different histopathologic anomalies detected in placentas from women with SARS-CoV-2 infection in pregnancy
| Histopathologic findings | Studies (n) | Cases (n/N) | Pooled proportions (95% CI) | I2 (%) |
|---|---|---|---|---|
| Maternal vascular malperfusion | 41 | 235/753 | 30.69 (20.3–42.1) | 88.4 |
| Fetal vascular malperfusion | 45 | 192/847 | 27.08 (19.2–35.6) | 82.1 |
| Acute inflammatory pathology | 53 | 176/819 | 22.68 (16.9–29.0) | 66.9 |
| Chronic inflammatory pathology | 49 | 152/735 | 25.65 (18.4–33.6) | 75.0 |
| Increased perivillous fibrin | 47 | 176/662 | 32.77 (24.1–42.0) | 77.3 |
| Intervillous thrombosis | 46 | 102/710 | 14.63 (9.7–20.2) | 63.0 |
| Other findings | 55 | 269/825 | 37.54 (28.0–47.5) | 84.5 |
| No placental pathology | 48 | 102/639 | 17.49 (10.9–25.2) | 74.0 |
CI, confidence interval.
Di Girolamo. SARS-CoV-2 infection and placenta. Am J Obstet Gynecol MFM 2021.