Table 6.
Pooled odds ratio of the different categorical outcomes explored in this systematic review
| Histologic findings | Studies (n) | Placentas examined (n/N) | Pooled OR (95% CI) | I2 (%) | P value (P<.05) |
|---|---|---|---|---|---|
| Maternal vascular malperfusion | 10 | 161/458 vs 226/779 | 1.82 (0.7–4.6) | 84.4 | .198 |
| Fetal vascular malperfusion | 11 | 115/535 vs 187/835 | 1.85 (1.3–2.6) | 67.6 | .002a |
| Acute inflammatory pathology | 11 | 95/499 vs 235/820 | 0.67 (0.4–1.2) | 64.2 | .204 |
| Chronic inflammatory pathology | 9 | 74/417 vs 105/712 | 1.94 (1.3–2.8) | 74.0 | .003a |
| Increased perivillous fibrin | 9 | 105/397 vs 46/656 | 6.78 (2.7–17.0) | 61.7 | <.001a |
| Intervillous thrombosis | 9 | 61/433 vs 38/671 | 3.23(2.0–5.2) | 85.5 | <.001a |
| Other findings | 11 | 165/499 vs 191/820 | 2.01 (1.4–2.7) | 73.8 | <.001a |
| No placental pathology | 8 | 35/385 vs 72/429 | 0.40 (0.2–0.6) | 86.0 | <.001a |
CI, confidence interval; OR, odds ratio.
a
p<0.05.
Di Girolamo. SARS-CoV-2 infection and placenta. Am J Obstet Gynecol MFM 2021.