Table 1.
Minimum inhibitory concentration of compounds presented in this study in BSA-free medium (7H9/glucose/casitone/tyloxapol)
| Strain | MIC (μM) |
Mutation | ||||||
|---|---|---|---|---|---|---|---|---|
| C1 | C2 | C3 | C4 | 4-AI | C5 | INH | ||
| WT | 1.56 | 3.12 | 6.25 | 3.12 | 4.68 | 0.39 | 0.12 | – |
| 5A | >100 | 75 | >100 | 75 | 4.68 | 0.39 | 0.12 | amiC K195∗ |
| 5B | >100 | 75 | >100 | 75 | 4.68 | 0.39 | 0.12 | amiC W238∗ |
| 5G | >100 | 75 | >100 | 75 | 4.68 | 0.39 | 0.12 | amiC S157F |
| 5H | >100 | 75 | >100 | 75 | 4.68 | 0.39 | 0.12 | amiC + g in aa352 |
| 5I | >100 | 75 | >100 | 75 | 4.68 | 0.39 | 0.12 | amiC + g in aa352 |
| 5J | 6.25 | 25 | >100 | 25 | 100 | 0.39 | 0.12 | trpB A168V |
| 5K | 6.25 | 25 | >100 | 25 | 100 | 0.39 | 0.12 | trpB A134V |
| 5L | 6.25 | 25 | >100 | 25 | 100 | 0.39 | 0.12 | trpE H170R |
| 5M | 6.25 | 25 | >100 | 25 | 100 | 0.098 | 0.12 | trpB D261G |
| 5N | 6.25 | 25 | >100 | 25 | 100 | 0.19 | 0.12 | trpA D54G |
| 5O | 6.25 | 25 | >100 | 25 | 100 | 0.19 | 0.12 | trpB D261G |