REAGENT or RESOURCE	SOURCE	IDENTIFIER
Bacterial and virus strains
M. tuberculosis H37Rv	Lab stock	N/A
M. bovis BCG	Lab stock	N/A
M. smegmatis mc2155	Lab stock	N/A
E. coli NEB5α	New England Biolabs	Cat# C2987H
E. coli BL21(DE3)	New England Biolabs	Cat# C2527H
Chemicals, peptides, and recombinant proteins
Middlebrook 7H9 broth base (Difco)	FisherScientific	Cat# DF0713-17-9
Middlebrook 7H11 agar base	Millipore Sigma	Cat# M0428-500G
Bovine Serum Albumin Fraction V	Millipore Sigma	Cat# 810535
Gibco Bacto Casitone	FisherScientific	Cat# DF0259-17-9
Tyloxapol	Sigma-Aldrich	Cat# T0307-10G
Tween 80	Sigma-Aldrich	Cat# P7949-500ML
DMEM growth medium	ThermoFisher	Cat# 11965118
Fetal Bovine Serum (FBS)	ThermoFisher	Cat# A4766801
Isoniazid	Sigma-Aldrich	Cat# I3377-5G
Ethionamide	Sigma-Aldrich	Cat# 1261004-200MG
Compounds C1 – C21	This manuscript	N/A
4-aminoindole	Sigma-Aldrich	Cat# 525022-500MG
L-Tryptophan	Sigma-Aldrich	Cat# 93659-10G
L-Serine	Sigma-Aldrich	Cat# 84959-25G
CdRP	This manuscript	N/A
IGP	This manuscript	N/A
4-amino-L-Tryptophan	This manuscript	N/A
5-amino-L-Tryptophan	Sigma-Aldrich	Cat# AC5H30533E13-1G
TrpE WT	This manuscript	N/A
TrpE H170R	This manuscript	N/A
TrpAB WT	This manuscript	N/A
TrpAB βA168V	This manuscript	N/A
TrpAB βD261G	This manuscript	N/A
E. coli TrpCF	This manuscript	N/A
GAPDH	Millipore Sigma	Cat# G2267-1KU
Critical commercial assays
CellTiter-Glo Luminescent Kit	Promega	Cat# G7573
BCA Protein Assay Kit	Pierce	Cat# 23227
Experimental models: cell lines
J774A.1	ATCC	ATCC TIB-67
Experimental models: organisms/strains
M. tuberculosis H37Rv + pMV306SNKdi-Psmyc-AmiC	This manuscript	N/A
M. tuberculosis H37Rv rpsL	This manuscript	N/A
M. tuberculosis H37Rv trpB A168V	This manuscript	N/A
M. tuberculosis H37Rv trpB A134V	This manuscript	N/A
M. tuberculosis H37Rv trpE H170R	This manuscript	N/A
Oligonucleotides
Oligonucelotides are listed in Table S5
Software and algorithms
GraphPad Prism	GraphPad	https://www.graphpad.com/scientific-software/prism/
SeqBuilder Pro	DNAStar	https://www.dnastar.com/software/
PyMol 2.2.3	Schrodinger, LLC	https://pymol.org/2/
ChemDraw	PerkinElmer	https://www.perkinelmer.com/category/chemdraw