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. 2021 Jul 5;14(5):1172–1182. doi: 10.1038/s41385-021-00423-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, f, h Representative immunohistochemical staining for CD3, pSTAT5, and Tbet in paraffin-embedded resected inflamed colonic tissue (visit S2) and paraffin-embedded tissue of the unaffected duodenum from the patient at time of diagnosis (visit S0) and PIBD control. b CD3, CD4, and CD8 mRNA and g IFNG mRNA expression in total resected colonic tissue of the patient and PIBD controls. c CD3, CD4, and CD8 mRNA and (i) HLAE mRNA expression in the epithelial layer isolated from resected colonic tissue of the patient and PIBD controls. d Representative immunofluorescent double staining of paraffin-embedded resected colonic tissue of the patient. Green = Ki67, red = CD3, blue = 4′,6-diamidino-2-phenylindole (DAPI) nuclear staining. e LPL were isolated from the inflamed colonic tissue of the patient. Frequencies of CD4⁺ and CD8⁺ cells in live CD3⁺ LPL, and Ki67 and CD25 expression by CD4⁺ and CD8⁺ LPL were analyzed by flow cytometry.