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. 2021 Aug 21;36(10):109679. doi: 10.1016/j.celrep.2021.109679

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© 2021 The Author(s)

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mAb binding of singly mutated rRBDs

Binding of the WT and the six indicated singly mutated rRBDs by MD65 (A), MD62 (B), MD29 (C), BL6 (D), and LY-CoV555 (E) mAbs was evaluated by biolayer interferometry (BLI). Each mAb was immobilized on a protein A sensor and incubated with each of the rRBD mutants (N501Y, S477N, E484K, N439K, K417N, and Y453F; depicted in Figure S3A) or WT rRBD as a control for 180 s. The figure includes representative graphs of at least two independent repeats of each experiment, yielding similar results.