Table 3.
Subgroup Analysis of the Relationship Between AG and 30-Day Mortality
| Characteristic | Number of Patients | HR (95% CI) | P-value | P for Interaction |
|---|---|---|---|---|
| Sex | ||||
| Female | 1,050 | 1.05 (1.03–1.08) | <0.0001 | 0.7543 |
| Male | 1,530 | 1.06 (1.04–1.08) | <0.0001 | |
| Age (years) | ||||
| <60 | 1,226 | 1.06 (1.04–1.09) | <0.0001 | 0.2294 |
| ≥60 | 1,354 | 1.04 (1.02–1.07) | 0.0005 | |
| Care unit | ||||
| CCU | 196 | 1.02 (0.93–1.11) | 0.7084 | 0.4727 |
| CSRU | 476 | 1.14 (1.03–1.25) | 0.0084 | |
| MICU | 1,268 | 1.05 (1.02–1.07) | 0.0004 | |
| SICU | 386 | 1.05 (1.00–1.10) | 0.0469 | |
| TSICU | 263 | 1.07 (1.00–1.13) | 0.0505 | |
| Causes of DIC | ||||
| Sepsis | 1,465 | 1.04 (1.02–1.06) | 0.0003 | 0.1526 |
| Cardiovascular diseases | 424 | 1.11 (1.02–1.21) | 0.0126 | |
| Trauma | 140 | 1.09 (1.00–1.19) | 0.0582 | |
| Others | 551 | 1.09 (1.04–1.15) | 0.0004 | |
| COPD | ||||
| No | 2,193 | 1.05 (1.03–1.07) | <0.0001 | 0.3802 |
| Yes | 387 | 1.08 (1.03–1.13) | 0.0028 | |
| Diabetes | ||||
| No | 2,091 | 1.05 (1.03–1.07) | <0.0001 | 0.2487 |
| Yes | 561 | 1.08 (1.04–1.12) | 0.0003 | |
| Renal failure | ||||
| No | 2,254 | 1.05 (1.03–1.07) | <0.0001 | 0.0310 |
| Yes | 326 | 1.10 (1.06, 1.14) | <0.0001 | |
| CRRT use | ||||
| No | 2,359 | 1.06 (1.03–1.08) | <0.0001 | 0.7379 |
| Yes | 221 | 1.05 (1.01–1.08) | 0.0053 | |
| Vasopressor drugs use | ||||
| No | 1,229 | 1.05 (1.02–1.09) | 0.0023 | 0.9986 |
| Yes | 1,351 | 1.05 (1.03–1.08) | <0.0001 | |
| Mechanical ventilation use | ||||
| No | 810 | 1.07 (1.04– 1.11) | 0.0001 | 0.2795 |
| Yes | 1,770 | 1.05 (1.03–1.07) | <0.0001 |
Abbreviations: CCU, Coronary Care Unit; CSRU, Cardiac Surgery Recovery Unit; MICU, Medical Intensive Care Unit; SICU, Surgical Intensive Care Unit; TSICU, Trauma/Surgical Intensive Care Unit; DIC, disseminated intravascular coagulation; COPD, chronic obstructive pulmonary disease; CRRT, continuous renal replacement therapy.