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SAD was induced in rats by bilateral icv infusion of STZ (3 mg/kg). The rats were treated with PF11 (2, 4, 8 mg·kg−1· d−1, ig) or a positive control drug donepezil (5 mg·kg−1· d−1, ig) for 4 weeks. Their cognitive function was assessed in the behavioral tests. All rats were sacrificed after the behavioral tests for Nissl staining, TEM, immunochemical analysis and Western blot analysis.
