Fig. 1. Scheme of the experimental procedure.

After a week of acclimatization, HD was induced in mice by injection of 3-NP twice daily for four days. The dose of 3-NP was 60 mg/kg on the first day, and 80 mg/kg 3-NP was administered from the second day to the fourth day. Half an hour before 3-NP injection, Rg1 was administered at doses of 10, 20, 40 mg/kg. The open field test and neurological scoring were carried out on the fifth day. All mice were sacrificed for further study.