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. 2021 Aug 20;11:16999. doi: 10.1038/s41598-021-96562-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Anti-ischemic effect of uridine treatment in the AMI and I/R models. (a) Size of the ischemic alteration zone and (b) T-wave amplitude on the EEG in the AMI model. AMI (n = 15), AMI + uridine (n = 6), AMI + uridine + 5-HD (n = 6). (c) Infarct area in the rat myocardium after 120 min of reperfusion in the I/R model. Abbreviations: AMI, acute myocardial ischemia; I/R, ischemia/reperfusion; 5-HD, 5-hydroxydecanoate; IA, infarct area; AAR, area at risk; LCA, the left coronary artery. The AAR was expressed as a percentage of the total area of the left ventricle, and the IA, as a percentage of the AAR. I/R (n = 9), I/R + uridine (n = 5), I/R + uridine + 5-HD (n = 6). All data are the mean ± SD. **p < 0.01 versus AMI (or I/R) group, ***p < 0.001 versus AMI (or I/R) group, ^##p < 0.01 versus AMI (or I/R) + uridine group, ^###p < 0.001 versus AMI (or I/R) + uridine group.