Table 3.
Effect of uridine on ATP and CrP concentrations, lipid peroxidation and the antioxidant status in the rat myocardium after 120 min of reperfusion.
| Groups | n | ATP (µmol/g wet tissue) | CrP (µmol/g wet tissue) | LPOs (OD532) | DC (OD232) | SOD activity (U/mg pr) | GSH (μmol/g wet tissue) |
|---|---|---|---|---|---|---|---|
| Sham-operated | 8 | 2.77 ± 0.26 | 6.22 ± 0.36 | 0.068 ± 0.002 | 6.50 ± 0.41 | 4.72 ± 0.11 | 33.48 ± 0.63 |
| I/R | 10 | 1.15 ± 0.24*** | 2.04 ± 0.62*** | 0.096 ± 0.004*** | 10.55 ± 0.61*** | 4.03 ± 0.12*** | 25.49 ± 0.78*** |
| I/R + uridine | 10 | 2.50 ± 0.14### | 4.71 ± 0.29 ### | 0.063 ± 0.005### | 7.69 ± 0.52## | 4.67 ± 0.09### | 31.65 ± 0.97### |
| I/R + uridine + 5-HD | 9 | 1.46 ± 0.12***,†† | 2.89 ± 0.29***,† | 0.084 ± 0.004†† | 11.12 ± 0.68***, ††† | 4.10 ± 0.20**, †† | 28.28 ± 0.78***,† |
I/R ischemia/reperfusion, 5-HD 5-hydroxydecanoate, CrP creatine phosphate, LPOs lipid hydroperoxides, DC diene conjugates, SOD superoxide dismutase, GSH reduced glutathione. All data are mean ± SEM (n = 8–10).
**p < 0.01 versus sham-operated group; ***p < 0.001 versus sham-operated group; ##p < 0.01 versus I/R group, ###p < 0.001 versus I/R group; †p < 0.05 versus I/R + uridine group; ††p < 0.01 versus I/R + uridine group; †††p < 0.001 versus I/R + uridine group. Significance of differences was determined by a one-way ANOVA followed by the Turkey’s multiple comparison Post Hoc test.