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. 2021 Aug 20;6:313. doi: 10.1038/s41392-021-00730-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — BCL9 is associated with CD155-CD226 checkpoint in CT26-CD8 T⁺ cell interaction. a Interaction analysis between CD8⁺ T and CT26 cells in vehicle group. b Interaction analysis between CD8⁺ T and CT26 cells in hsBCL9_CT-24 treated group. c Interaction analysis between CD8⁺ T and CT26 cells in NT-shRNA group. d Interaction analysis between CD8⁺ T and CT26 cells in Bcl9-shRNA group. e Circos plots of all of the putative ligand–receptor interactions in vehicle and hsBCL9_CT-24 treated groups. The color of the line represents the average expression of the ligand–receptor pair in the pair of cells, and the thickness of the line represents the significance of the ligand–receptor enrichment in the pair of cells. The solid line represents the interaction of the hsbcl9_CT-24 group, and the dotted line represents the interaction of the vehicle group. f Circos plots of all of the putative ligand–receptor interactions in NT-shRNA and Bcl9-shRNA groups. The solid line represents the interaction of Bcl9-shRNA group, and the dotted line represents the interaction of the NT-shRNA group. g Heatmap analysis of CT26 tumor pretreated with vehicle or hsBCL9_CT-24 (i.p., 25 mg/kg). h GSEA analysis of CT26 tumor pretreated with vehicle or hsBCL9_CT-24 (i.p., 25 mg/kg). i Scatter and boxplot analyses of CD8⁺ T cell infiltration associated with BCL9 expression level in TCGA. j Scatter and boxplot analyses of CD226 expression associated with BCL9 expression level in TCGA. P < 0.05 means statistically significant.