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. 2021 Aug 20;6:313. doi: 10.1038/s41392-021-00730-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — BCL9 and CD155-CD226 are associated with APC mutation, which is correlated with patient survival after immune checkpoint inhibitor treatment. a Cell–cell interaction in scRNA-seq database for human CRC samples. b Boxplot analyses of BCL9 expression associated with APC mutation level in TCGA. c Boxplot analyses of CD226 expression associated with APC mutation level in TCGA. d Boxplot analyses of CD155/PVR expression associated with APC mutation level in TCGA. e Box plots showing expression differences of CTLA-4 between APC non-mutation and APC mutation tumors. f Box plots showing expression differences of PDCD1 (PD-L1) between APC non-mutation and APC mutation tumors. g Box plots showing expression differences of CD274 (PD-L1) between APC non-mutation and APC mutation tumors. h Correlation of APC mutation with immunotherapy outcome in CRC specimens. OS, overall survival. P < 0.05 means statistically significant.