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. 2021 Aug 20;11:16981. doi: 10.1038/s41598-021-96654-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of dosing software on unbound cefazolin concentration. By entering renal parameters and dialysis settings in a dosing software (thecaddy.de)¹¹ we received a recommended dose of cefazolin for each patient and each day. We were then able to calculate the hypothetical plasma concentration using the recommended dose and the measured cefazolin clearance of that day. This figure shows the actual measured free plasma concentrations of cefazolin (blue circles) using 6000 mg/d and the calculated concentration if we had used dosing software (orange circles). The y-axis shows the free plasma concentration of cefazolin in mg/L and the red lines show the target range of (unbound) cefazolin with 4 times and 8 times ECOFF (2 mg/L).