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. 2021 Apr 23;42(9):1486–1497. doi: 10.1038/s41401-021-00657-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a The chemical structural formula of triptolide. b Triptolide suppressed the proliferation of NCI-H1299 cells in a dose-dependent manner. c, d The effect of triptolide on the migration of NCI-H1299 cells determined by wound-healing assays. e, f The effect of triptolide on the migration and invasion of NCI-H1299 cells determined by Transwell migration and invasion assays. Representative images (×100 magnification) are shown in e. Quantitative data were calculated using ImageJ, analyzed by using GraphPad Prism 5.0 and are shown in f and g. TPL triptolide. The data are presented as the mean ± SEM, n = 3. ***P < 0.001 vs. the vehicle group.