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. 2021 Apr 23;42(9):1486–1497. doi: 10.1038/s41401-021-00657-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, b β-Catenin vector transfection increased β-catenin expression, as detected by Western blotting and RT-qPCR assays. c, d The effects of β-catenin overexpression on the triptolide-mediated inhibitory effect on the migration and invasion of NCI-H1299 and NCI-H460 cells. NCI-H1299 and NCI-H460 cells were transfected with NC vector or β-catenin vector and then subjected to Transwell migration assays (c) and invasion assays (d). The images were taken at ×100 magnification. e, f The effect of triptolide on EMT in NCI-H1299 and NCI-H460 cells was weakened by β-catenin overexpression. After transfection, the cells were collected and used for Western blotting and RT-qPCR assays. The results of Western blotting and RT-qPCR assays are shown in e and f, respectively. TPL triptolide. The data are presented as the mean ± SEM, n = 3. ***P < 0.001 compared with the vector group, ^###P < 0.001 vs. the β-catenin vector group.