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. 2021 Apr 23;42(9):1486–1497. doi: 10.1038/s41401-021-00657-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a, b The antitumor effect of triptolide on the NCI-H1299 xenograft model. Tumor-bearing mice were administered vehicle and triptolide (1.5 and 0.75 mg/kg) every 2 days for a total of 18 days. At the end of the experiment, the mice were sacrificed, and the tumors were harvested. The tumor volume curve and tumor weight are presented in a and b, respectively. c, d The effect of triptolide on the expression of β-catenin and EMT markers in NCI-H1299 xenograft tumors. Immunohistochemical assays were conducted to detect β-catenin, N-cadherin, vimentin, E-cadherin, and ZO-1 expression. Representative images and quantitative data are presented in c and d. The images were taken at ×100 magnification. e, f The effect of triptolide on the lung metastasis of NCI-H1299 cells. After tail vein injections of NCI-H1299 cells, the mice were administered triptolide (1.5 mg/kg) three times per week for a total of 6 weeks. H&E staining of lung sections and quantitative data of metastatic foci are shown in e and f. H&E images were taken at ×100 magnification. TPL triptolide. The data are presented as the mean ± SEM, n = 5 in vehicle group. n = 6 in TPL group. ***P < 0.001 vs. the vehicle group.