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. 2021 Feb 4;36(4):823–828. doi: 10.1007/s12250-021-00347-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Clinical characteristics of PRV infection patients and sero-prevalence of PRV-gE in domestic pigs in China. A Clinical manifestations and prognosis of PRV infection patients in China. At the early stage of infection, fever (100%, 23/23), respiratory signs (72.7%, 16/22) and headache (57.9%, 11/19) were often observed. Then, rapidly progressed to neurological disorders, including seizures/convulsions (95.7%, 22/23) and disturbance of consciousness (95.7%, 22/23). Additionally, 60% (12/20) of the patients had severe visual impairment and 77.3% (17/22) complicated by pulmonary inflammation. All patients were diagnosed with viral encephalitis, except for one who was diagnosed with endophthalmitis alone. The prognosis was very bad: 17.4% (4/23) of the patients died, 17.4% (4/23) developed blindness, 21.7% (5/23) showed severe visual impairment, and 65.2% (15/23) of the patients had severe central nervous system (CNS) symptoms such as persistent vegetative status, memory loss and only could follow simple instructions. B Sero-prevalence of PRV-gE in central China from 2014 to 2019. The positive rate of PRV-gE antibodies ranged from 37.0 to 53.5% and from 68.0 to 78.0% at serum sample level and pig farm level, respectively.