Table 1.

Summary information of the human PRV infection cases in China.

Case	Common information						Clinical manifestation
	Age (y)	Sex	Occupation	Contact history	Place of infection	Year	Fever	Respiratory failure	Headache	Pneumonia	Visual impairment	Seizures	Disturbance of consciousness	Viral encephalitis	Ocular inflammation
1	38	Male	Butcher	Injury	Shandong	2017	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	N.A
2	55	Male	Pork dealer	Pork	Inner Mongolia	2017	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes	N.A
3	51	Male	Cook	Pork	Inner Mongolia	2017	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	N.A
4	42	Female	Butcher	Pigs/pork	Hebei	2016	Yes	No	No	No	Yes	Yes	Yes	Yes	Yes
5	46	Female	Swineherd	Sewage	Jiangxi	2017	Yes	No	Yes	No	Yes	No	No	No	Yes
6	44	Male	Sick pig handler	Diseased pigs; pork	Shandong	2019	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes	Yes
7	59	Male	Swineherd	Needle injury	Hebei	2019	Yes	No	No	No	Yes	Yes	Yes	Yes	N.A
8	50	Male	Butcher	Injury at work	Shandong	2018	Yes	No	Yes	Yes	No	Yes	Yes	Yes	N.A
9	50	Female	Pork cutter	Injury at work	Shandong	2018	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	N.A
10	43	Male	Sick pig handler	Injury at work	Shandong	2018	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes	N.A
11	59	Male	Pork cutter	Injury at work	Shandong	2018	Yes	Yes	No	Yes	No	Yes	Yes	Yes	N.A
12	50	Male	Pork cutter	N.A	Shandong	2018	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes	N.A
13	46	Male	Veterinarian	Injury/ dead pigs	Shandong	2018	Yes	No	Yes	No	No	Yes	Yes	Yes	N.A
14	25	Male	Veterinarian	Diseased pigs	Hubei	2018	Yes	No	Yes	Yes	Yes	Yes	Yes	Yes	N.A
15	25	Male	Butcher	Pigs/pork	Henan	2019	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	N.A
16	49	Male	Butcher	Pork	Henan	2019	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	N.A
17	43	Male	Veterinarian	Diseased pigs	Shandong	2018	Yes	Yes	Yes	Yes	No	Yes	Yes	Yes	N.A
18	44	Male	Pork vendor	Injury	Anhui	2019	Yes	Yes	No	No	Yes	Yes	Yes	Yes	N.A
19	N.A	Male	Butcher	N.A	Shandong	2018	Yes	Yes	N.A	Yes	N.A	Yes	Yes	Yes	N.A
20	N.A	Male	Swineherd	N.A	Hebei	2018	Yes	Yes	N.A	Yes	Yes	Yes	Yes	Yes	N.A
21	N.A	Male	Driver	N.A	Guangdong	2018	Yes	Yes	N.A	Yes	N.A	Yes	Yes	Yes	N.A
22	N.A	Female	Pork dealer	N.A	Beijing	2011	Yes	Yes	N.A	Yes	N.A	Yes	Yes	Yes	N.A
23	49	Male	Slaughterer	N.A	Anhui	2019	Yes	N.A	Yes	N.A	Yes	Yes	Yes	Yes	Yes

Case	Diagnosis			Clinical outcome	References
	Vitreous humor (NGS)	Cerebrospinal fluid (NGS)	Antibody (ELISA)
1	N.A	+	+	Minimally conscious state	Zhao et al. (2018)
2	N.A	+	+	Death
3	N.A	+	+	Death
4	N.A	N.A	N.A	Minimally conscious state; Blindness
5	+	–	+	Visually impaired	Ai et al. (2018)
6	+	+	N.A	Persistent vegetative state; Visually impaired	Wang et al. (2019)
7	N.A	+	+	Follow simple instructions; Mild cognitive deficit; Blindness	Zheng et al. (2019)
8	N.A	+	N.A	Slow responses, Occasional seizures	Yang X et al. (2019)
9	N.A	+	N.A	Ventilator-dependent
10	N.A	+	N.A	Follow simple instructions; Blurry vision
11	N.A	+	N.A	Ventilator-dependent
12	N.A	+	N.A	Slow responses; Blindness
13	N.A	+	+	N.A	Yang H et al. (2019)
14	–	+	+	Blindness	Liu et al. (2020)
15	–	+	+	Mild memory impairment
16	–	+	+	Minimally conscious state
17	–	+	+	Persistent vegetative state
18	N.A	+	+	Follow simple instructions; blurry vision	Wang et al. (2020)
19	N.A	+	+	Death	Fan et al. (2020)
20	N.A	+	+	Memory loss and bilateral hand tremor; Visual impairment
21	N.A	+	+	Follow simple instructions
22	N.A	+	–	Death
23	+	N.A	N.A	N.A	Hu et al. (2020)

N.A. not available.